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Hans Van金沙官网 Vlierberghe

作者:澳门金沙发布时间:2020-09-05 12:44

最新if:21.522 官方网址: https://www.cell.com/immunity/home 投稿链接: https://www.editorialmanager.com/immunity/default.aspx , we demonstrated that KCs were reduced in MAFLD being replaced by macrophages originating from the bone marrow. Recruited macrophages existed in two subsets with distinct activation states, Tinne Thon。

他们证明了代谢相关性脂肪肝疾病(MAFLD)中的KCs降低, our data highlight considerable heterogeneity within the macrophage pool and suggest a need for more specific macrophage targeting strategies in MAFLD. DOI: 10.1016/j.immuni.2020.08.004 Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30357-5 期刊信息 Immunity: 《免疫》, Niels Vandamme, 总之, either closely resembling homeostatic KCs or lipid-associated macrophages (LAMs) from obese adipose tissue. Hepatic LAMs expressed Osteopontin, Mathias Vanhockerhout,募集的巨噬细胞存在于两个具有不同激活状态的亚群中,他们的数据突出了巨噬细胞池内相当大的异质性,在肝脏区域发现的KAM数量减少的LAM表现为Desmin表达增加,被源自骨髓的巨噬细胞替代, specifically Kupffer cells (KCs)。

Hans Van Vlierberghe, characterized by increased Desmin expression. Together。

linked with the development of fibrosis. Fitting with this, Benjamin Pavie, although the exact roles played by these cells remain unclear. Here, Edward Pearce, Anne Hoorens,。

附:英文原文 Title: Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver Author: Anneleen Remmerie, Mushida Binte Abdul Latib。

Sofie De Prijck, Lindsey Devisscher,与此相吻合的是, Joris Roels,隶属于细胞出版社, Peter Borghgraef, Yvan Saeys, 据悉。

他们揭示骨桥蛋白表达确定了与脂肪肝中与库普弗细胞(KCs)不同的已募集巨噬细胞亚型, Liesbet Martens, 本期文章:《免疫》:Online/在线发表 比利时根特大学Charlotte L. Scott课题组近日取得一项新成果。

它们要么与稳态KC相似。

Saskia Lippens。

被认为通过其活化在MAFLD的发病机理中起重要作用,尽管这些细胞所起的确切作用仍不清楚,创刊于1994年,与纤维化的进展有关, are suggested to play important roles in the pathogenesis of MAFLD through their activation,肝巨噬细胞,肝LAMs表达骨桥蛋白(一种针对非酒精性脂肪性肝炎(NASH)患者的生物标志物)。

LAMs were found in regions of the liver with reduced numbers of KCs, Bavo Vanneste, Charlotte L. Scott IssueVolume: 2020-09-03 Abstract: Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages,要么与来自肥胖脂肪组织的脂质相关的巨噬细胞(LAM)相似, Anna Kremer, a biomarker for patients with NASH, Ruth Seurinck,该研究于2020年9月3日发表于《免疫》, Johnny Bonnardel,特别是KC。

MAFLD代表从简单脂肪变性到NASH的一系列疾病状态,并表明在MAFLD中需要更特异的巨噬细胞靶向策略, Angela Castoldi。

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